Genome location: Pf3D7_14_v3:1,232,648..1,237,614(-)
Genome classification: Core
Product Description: surface-related antigen SRA
SignalP Peptide: MFLSSKKRRVFVLFMYFFVQNVNS
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Function | GO:0046812 | host cell surface binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.05 | 0.97 |
| Schizont | expressed | 1.41 | 0.39 |
| Gametocyte | possibly expressed | 0.10 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1431400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.408 | MFS: -2.45 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILF1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 43 | 30 | 52 |
| disruptive | 56 | 122 | 74 | 190 |
| missense | 33 | 82 | 59 | 139 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 95 | 45 | 47 |
| disruptive | 105 | 299 | 120 | 276 |
| missense | 50 | 198 | 87 | 192 |
PlasmoDB Total SNPs: 141
Non-coding: 47 | Synonymous: 56 | Nonsynonymous: 38 | Stop Codon: 0
Protein Length: 990 | Molecular Weight (kDa): 116.104
UniProt ID(s): Q8ILF1
PDB ID(s): None
Isoelectric Point: 8.41
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29912472 | Functional Characterization of Plasmodium falciparum Surface-Related Antigen as aPotential Blood-Stage Vaccine Target. | Amlabu E, Mensah-Brown H, ..., Awandare GA | 10.1093/infdis/jiy222 |
| 38419946 | Systematic Review and Meta-Analysis of Congenital Toxoplasmosis Diagnosis:Advances and Challenges | Franco PS, Scussel ACMO, ..., Gomes AO | 10.1155/2024/1514178 |