Product Description: 60S ribosomal protein L14, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0042273 | ribosomal large subunit biogenesis |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.11 | 0.24 |
| Trophozoite | expressed | 2.19 | 0.16 |
| Schizont | expressed | 0.61 | 0.66 |
| Gametocyte | expressed | 1.60 | 0.27 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1431700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.481 | MFS: -3.498 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1013100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILE8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P00189 | Cholesterol side-chain cleavage enzyme, mitochondrial | OrthoDB | US9725436, Entry 1US9725436, Entry 2US9725436, Entry 3US9725436, Entry 4... | |
| P15539 | Cytochrome P450 11B2, mitochondrial | OrthoDB | CHEMBL3623830FadrozoleCHEMBL3099695CHEMBL4099824... | |
| P19099 | Cytochrome P450 11B2, mitochondrial | OrthoDB | (3-Pyridylmethylene)indane 1a(3-Pyridylmethylene)indane 1b(3-Pyridylmethylene)tetrahydronaphthalene 3a(3-Pyridylmethylene)tetrahydronaphthalene 3b... | |
| Q07973 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | Homo sapiens | OrthoDB | 24COOH-25(OH)D3Ketoconazole (k)AB47VIMI... |
| P15538 | Cytochrome P450 11B1, mitochondrial | Homo sapiens | OrthoDB | (3-Pyridylmethylene)indane 1a(3-Pyridylmethylene)indane 1b(3-Pyridylmethylene)tetrahydronaphthalene 3a(3-Pyridylmethylene)tetrahydronaphthalene 3b... |
| P14137 | Cholesterol side-chain cleavage enzyme, mitochondrial | Rattus norvegicus | OrthoDB | KetoconazoleCHEMBL319160KetoconazoleCHEMBL328863... |
| P15150 | Cytochrome P450 11B1, mitochondrial | Bos taurus | OrthoDB | KetoconazoleKetoconazoleCHEMBL319160CHEMBL328863... |
| O35084 | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | OrthoDB | CHEMBL1171494CHEMBL3329767CHEMBL3329768CHEMBL3329769... | |
| A0A0D9R9Y2 | Cytochrome P450 family 11 subfamily B member 2 | OrthoDB | US9181272, 1US9181272, 2US9181272, 3US9181272, 4... | |
| Q02318 | Sterol 26-hydroxylase, mitochondrial | Homo sapiens | OrthoDB | CHEMBL1253780CHEMBL1253863CHEMBL1253864CHEMBL1253946... |
| Q09128 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | Rattus norvegicus | OrthoDB | CHEMBL185684CHEMBL361073CHEMBL183636CHEMBL186016... |
| O15528 | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | Homo sapiens | OrthoDB | AB47VIMIKetoconazole (k)24COOH-25(OH)D3... |
Ortholog Group (OrthoMCL): OG6_100966
Most Similar Human Ortholog: E7EPB3
TM-align score: 0.87 | RMSD: 1.66
Seq Identity: 0.31 | Length: 124 / 165
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000188846 | ribosomal protein L14 |
Protein Length: 165 | Molecular Weight (kDa): 19.297
UniProt ID(s): Q8ILE8
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 10.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002784 | Ribosomal protein L14e domain |
| InterPro | IPR008991 | Translation protein SH3-like domain superfamily |
| InterPro | IPR039660 | Ribosomal protein L14 |
| InterPro | IPR041985 | Ribosomal protein L14, KOW motif |
| PFam | PF01929 | Ribosomal protein L14e domain |
| Superfamily | SSF50104 | Translation protein SH3-like domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 9 | 3 | 12 |
| disruptive | 0 | 5 | 7 | 19 |
| missense | 0 | 5 | 6 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 17 | 9 | 12 |
| disruptive | 5 | 20 | 15 | 43 |
| missense | 1 | 16 | 12 | 28 |
PlasmoDB Total SNPs: 114
Non-coding: 110 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |