Genome location: Pf3D7_14_v3:1,252,881..1,257,284(+)
Genome classification: Core
Product Description: inner membrane complex suture component, putative
SignalP Peptide: N/A
# Transmembrane Domains: 10
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0070258 | inner membrane pellicle complex |
| Component | GO:0016020 | membrane |
| Function | GO:0022857 | transmembrane transporter activity |
| Process | GO:0055085 | transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.03 | 0.98 |
| Schizont | expressed | 0.22 | 0.85 |
| Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1431900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.258 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILE6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 28 | 15 | 42 |
| disruptive | 15 | 74 | 40 | 113 |
| missense | 10 | 70 | 39 | 97 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 64 | 28 | 40 |
| disruptive | 30 | 158 | 87 | 190 |
| missense | 18 | 134 | 80 | 151 |
PlasmoDB Total SNPs: 186
Non-coding: 137 | Synonymous: 32 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 732 | Molecular Weight (kDa): 86.928
UniProt ID(s): Q8ILE6
PDB ID(s): None
Isoelectric Point: 8.66
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007603 | Choline transporter-like |
| PFam | PF04515 | Choline transporter-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25691595 | Novel components of the Toxoplasma inner membrane complex revealed by BioID. | Chen AL, Kim EW, ..., Bradley PJ | 10.1128/mBio.02357-14 |
| 27128092 | Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. | Swearingen KE, Lindner SE, ..., Sinnis P | 10.1371/journal.ppat.1005606 |