PF3D7_1432000 (SYN11)

Genome location: Pf3D7_14_v3:1,256,926..1,259,113(-)

Genome classification: Core

Function and Localization

Product Description: syntaxin, Qa-SNARE family

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0031201	SNARE complex
Component	GO:0012505	endomembrane system
Component	GO:0016021	integral component of membrane
Function	GO:0005484	SNAP receptor activity
Function	GO:0000149	SNARE binding
Process	GO:0006886	intracellular protein transport
Process	GO:0048278	vesicle docking
Process	GO:0006906	vesicle fusion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.13	0.94
Trophozoite	possibly expressed	0.65	0.64
Schizont	expressed	0.18	0.89
Gametocyte	not expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1432000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.347 | MFS: -3.418 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1012900)

Relative Growth Rate: 0.08 ± 0.17
Confidence: 4.95

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILE4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100497

Most Similar Human Ortholog: A0A0C4DFZ1

TM-align score: 0.65 | RMSD: 3.77

Seq Identity: 0.12 | Length: 218 / 442

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000099365	syntaxin 1B
ENSG00000106089	syntaxin 1A
ENSG00000111450	syntaxin 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	18	6	34
disruptive	27	39	21	49
missense	8	24	18	38

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	33	19	37
disruptive	39	79	23	88
missense	12	54	20	57

PlasmoDB Total SNPs: 103

Non-coding: 56 | Synonymous: 27 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 442 | Molecular Weight (kDa): 52.849

UniProt ID(s): Q0ZAF0, Q8ILE4

PDB ID(s): None

Isoelectric Point: 8.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006011	Syntaxin, N-terminal domain
InterPro	IPR010989	SNARE
PFam	PF00804	Syntaxin, N-terminal domain
Superfamily	SSF47661	SNARE