Genome location: Pf3D7_14_v3:1,260,840..1,263,051(+)
Genome classification: Core
Product Description: voltage-dependent anion-selective channel protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071944 | cell periphery |
| Component | GO:0005741 | mitochondrial outer membrane |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Function | GO:0008308 | voltage-gated anion channel activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.13 | 0.93 |
| Trophozoite | expressed | 0.33 | 0.79 |
| Schizont | expressed | 0.07 | 0.95 |
| Gametocyte | expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1432100
Resistome Missense Mutations: E101K
Resistome Compounds with Missense Mutations: BI-2536
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.513 | MFS: -2.559 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1012800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILE3
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=8.78) with 7WAJ (Global RMSD=17.59)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 15 | 5 | 13 |
| disruptive | 4 | 22 | 9 | 19 |
| missense | 4 | 22 | 9 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 26 | 11 | 24 |
| disruptive | 9 | 39 | 19 | 53 |
| missense | 8 | 32 | 16 | 37 |
PlasmoDB Total SNPs: 166
Non-coding: 142 | Synonymous: 15 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 289 | Molecular Weight (kDa): 33.267
UniProt ID(s): Q8ILE3
PDB ID(s): None
Isoelectric Point: 9.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001925 | Porin, eukaryotic type |
| InterPro | IPR027246 | Eukaryotic porin/Tom40 |
| PFam | PF01459 | Eukaryotic porin/Tom40 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |