PF3D7_1432200

Genome location: Pf3D7_14_v3:1,263,521..1,269,011(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.22	0.88
Schizont	possibly expressed	1.21	0.45
Gametocyte	not expressed	0.39	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1432200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.21 | #Insertions: 15

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILE1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532502

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	68	44	101
disruptive	43	186	118	295
missense	23	171	105	247

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	29	143	68	121
disruptive	91	472	231	500
missense	44	372	170	344

PlasmoDB Total SNPs: 180

Non-coding: 44 | Synonymous: 86 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 1670 | Molecular Weight (kDa): 201.686

UniProt ID(s): Q8ILE1

PDB ID(s): None

Isoelectric Point: 9.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A