PF3D7_1432300

Genome location: Pf3D7_14_v3:1,269,368..1,274,693(-)

Genome classification: Core

Function and Localization

Product Description: importin, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Component	GO:0005635	nuclear envelope
Process	GO:0006606	protein import into nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.13	0.93
Trophozoite	possibly expressed	0.36	0.78
Schizont	expressed	0.70	0.61
Gametocyte	expressed	0.77	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1432300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.947 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILE0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146140

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	70	30	99
disruptive	85	187	86	211
missense	64	142	76	173

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	134	58	109
disruptive	141	343	157	350
missense	98	261	128	246

PlasmoDB Total SNPs: 208

Non-coding: 37 | Synonymous: 72 | Nonsynonymous: 99 | Stop Codon: 0

Protein Information

Protein Length: 1639 | Molecular Weight (kDa): 196.97

UniProt ID(s): Q8ILE0

PDB ID(s): None

Isoelectric Point: 6.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001494	Importin-beta, N-terminal domain
InterPro	IPR016024	Armadillo-type fold
PFam	PF03810	Importin-beta, N-terminal domain
Superfamily	SSF48371	Armadillo-type fold