PF3D7_1432400 (LRR5)

Genome location: Pf3D7_14_v3:1,275,758..1,282,905(-)

Genome classification: Core

Function and Localization

Product Description: leucine-rich repeat protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.13	0.92
Schizont	not expressed	0.11	0.93
Gametocyte	not expressed	0.71	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1432400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.38 | #Insertions: 14

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILD9

"Best" AlphaFill ligand hit: BU3 ((r,r)-2,3-butanediol, Local RMSD=0.05) with 3W3G (Global RMSD=3.18)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105353

Most Similar Human Ortholog: H3BUS4

TM-align score: 0.76 | RMSD: 2.02

Seq Identity: 0.28 | Length: 103 / 1504

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000131951	leucine rich repeat containing 9

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	64	43	102
disruptive	33	118	77	193
missense	22	103	62	170

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	141	69	90
disruptive	63	290	130	344
missense	38	224	107	256

PlasmoDB Total SNPs: 299

Non-coding: 215 | Synonymous: 49 | Nonsynonymous: 35 | Stop Codon: 0

Protein Information

Protein Length: 1504 | Molecular Weight (kDa): 180.941

UniProt ID(s): Q2TFW4, Q8ILD9

PDB ID(s): None

Isoelectric Point: 8.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR003591	Leucine-rich repeat, typical subtype
PFam	PF13855	Leucine-rich repeat
Superfamily	SSF52058	N/A
Superfamily	SSF52075