PF3D7_1432800

Genome location: Pf3D7_14_v3:1,292,531..1,295,607(-)

Genome classification: Core

Function and Localization

Product Description: HP12 protein homolog, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005802	trans-Golgi network

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.21	0.89
Trophozoite	expressed	0.85	0.55
Schizont	expressed	0.46	0.72
Gametocyte	expressed	0.55	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1432800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.194 | MFS: -2.63 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1012100)

Modification: Disrupted | RMgm-2768

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILD4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532627

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	27	15	33
disruptive	27	77	49	130
missense	13	61	44	111

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	52	27	51
disruptive	52	184	101	173
missense	29	144	89	143

PlasmoDB Total SNPs: 148

Non-coding: 80 | Synonymous: 28 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 733 | Molecular Weight (kDa): 85.708

UniProt ID(s): Q8ILD4

PDB ID(s): None

Isoelectric Point: 6.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR031615	MYND-like zinc finger, mRNA-binding
PFam	PF15801	MYND-like zinc finger, mRNA-binding
Superfamily	N/A	N/A