Genome location: Pf3D7_14_v3:1,298,143..1,299,264(-)
Genome classification: Core
Product Description: H/ACA ribonucleoprotein complex subunit 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031429 | box H/ACA snoRNP complex |
| Component | GO:0090661 | box H/ACA telomerase RNP complex |
| Function | GO:0034513 | box H/ACA snoRNA binding |
| Function | GO:0070034 | telomerase RNA binding |
| Process | GO:0031118 | rRNA pseudouridine synthesis |
| Process | GO:0031120 | snRNA pseudouridine synthesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.95 | 0.57 |
| Trophozoite | no data | 0.85 | 0.53 |
| Schizont | no data | 0.14 | 0.91 |
| Gametocyte | no data | 0.45 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1433000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.189 | MFS: -2.549 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3I4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102021
Most Similar Human Ortholog: Q9NPE3
TM-align score: 0.90 | RMSD: 1.04
Seq Identity: 0.61 | Length: 54 / 55
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000182117 | NOP10 ribonucleoprotein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 21
Non-coding: 19 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 55 | Molecular Weight (kDa): 6.566
UniProt ID(s): C6S3I4
PDB ID(s): None
Isoelectric Point: 10.67
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007264 | H/ACA ribonucleoprotein complex, subunit Nop10 |
| InterPro | IPR036756 | H/ACA ribonucleoprotein complex, subunit Nop10 superfamily |
| PFam | PF04135 | H/ACA ribonucleoprotein complex, subunit Nop10 |
| Superfamily | SSF144210 | H/ACA ribonucleoprotein complex, subunit Nop10 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 37358014 | Gene expression profiling in whole blood stimulated ex vivo withlipopolysaccharide as a tool to predict post-stroke depressive symptoms:Proof-of-concept study | Piechota M, Hoinkis D, ..., Dziedzic T | 10.1111/jnc.15902 |