PF3D7_1433100

Genome location: Pf3D7_14_v3:1,299,666..1,303,727(+)

Genome classification: Core

Function and Localization

Product Description: HID1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005797	Golgi medial cisterna
Component	GO:0000138	Golgi trans cisterna
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.15	0.92
Trophozoite	expressed	0.48	0.71
Schizont	expressed	0.22	0.85
Gametocyte	expressed	0.45	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1433100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.67 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1040300)

Relative Growth Rate: 0.68 ± 0.20
Confidence: 4.64

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILD2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103153

Most Similar Human Ortholog: Q8IV36

TM-align score: 0.73 | RMSD: 4.40

Seq Identity: 0.19 | Length: 656 / 1123

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000167861	HID1 domain containing

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	51	37	63
disruptive	48	136	65	195
missense	23	92	53	164

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	114	56	78
disruptive	91	299	145	319
missense	44	220	116	222

PlasmoDB Total SNPs: 123

Non-coding: 42 | Synonymous: 52 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 1123 | Molecular Weight (kDa): 134.896

UniProt ID(s): Q8ILD2

PDB ID(s): None

Isoelectric Point: 8.61

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026705	Hid-1/Ecm30
PFam	PF09742	N/A
Superfamily	N/A	N/A