PF3D7_1433200

Genome location: Pf3D7_14_v3:1,304,028..1,308,159(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.09	0.95
Schizont	not expressed	0.10	0.94
Gametocyte	not expressed	0.60	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1433200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.986 | MFS: -0.868 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILD1

"Best" AlphaFill ligand hit: DEQ (dequadin, Local RMSD=0.07) with 3BR2 (Global RMSD=25.99)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533532

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	57	39	72
disruptive	34	198	131	288
missense	28	163	109	233

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	126	43	88
disruptive	89	461	196	407
missense	58	361	152	280

PlasmoDB Total SNPs: 174

Non-coding: 24 | Synonymous: 97 | Nonsynonymous: 52 | Stop Codon: 1

Protein Information

Protein Length: 1267 | Molecular Weight (kDa): 152.262

UniProt ID(s): Q8ILD1

PDB ID(s): None

Isoelectric Point: 8.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A