Genome location: Pf3D7_14_v3:1,309,923..1,312,200(+)
Genome classification: Core
Product Description: histone-binding protein RBBP7, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0042393 | histone binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0031497 | chromatin assembly |
| Process | GO:0006333 | chromatin assembly or disassembly |
| Process | GO:0006338 | chromatin remodeling |
| Process | GO:0006334 | nucleosome assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.06 | 0.96 |
| Schizont | expressed | 0.12 | 0.91 |
| Gametocyte | expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1433300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.488 | MFS: -2.479 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1011600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1011600)
Modification: Disrupted | RMgm-2767
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILD0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101102
Most Similar Human Ortholog: Q5JP02
TM-align score: 0.91 | RMSD: 1.13
Seq Identity: 0.33 | Length: 166 / 428
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000102054 | RB binding protein 7, chromatin remodeling factor |
| ENSG00000162521 | RB binding protein 4, chromatin remodeling factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 9 | 22 |
| disruptive | 5 | 17 | 14 | 42 |
| missense | 5 | 16 | 14 | 36 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 36 | 13 | 24 |
| disruptive | 9 | 55 | 35 | 105 |
| missense | 8 | 50 | 30 | 58 |
PlasmoDB Total SNPs: 176
Non-coding: 142 | Synonymous: 26 | Nonsynonymous: 7 | Stop Codon: 1
Protein Length: 428 | Molecular Weight (kDa): 50.175
UniProt ID(s): Q8ILD0
PDB ID(s): None
Isoelectric Point: 4.4
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR022052 | Histone-binding protein RBBP4, N-terminal |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| PFam | PF12265 | Histone-binding protein RBBP4, N-terminal |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32363442 | The multifaceted histone chaperone RbAp46/48 in Plasmodium falciparum: structuralinsights, production, and characterization. | Kaushik M, Nehra A, ..., Gill R | 10.1007/s00436-020-06669-5 |
| 32206492 | Unraveling CAF-1 family in Plasmodium falciparum: comparative genome-wideidentification and phylogenetic analysis among eukaryotes, expression profilingand protein-protein interaction studies | Kaushik M, Nehra A, Gill SS, Gill R | 10.1007/s13205-020-2096-7 |