Genome location: Pf3D7_14_v3:1,311,928..1,330,437(-)
Genome classification: Core
Product Description: PHD finger protein PHD2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 12
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000123 | histone acetyltransferase complex |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.95 | 0.62 |
| Trophozoite | expressed | 2.86 | 0.08 |
| Schizont | expressed | 2.54 | 0.23 |
| Gametocyte | expressed | 2.23 | 0.14 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1433400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.177 | MFS: -2.755 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105638
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 5757
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000078403 | MLLT10 histone lysine methyltransferase DOT1L cofactor |
| ENSG00000275023 | MLLT6, PHD finger containing |
| ENSG00000275851 | MLLT6, PHD finger containing |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 48 | 267 | 151 | 350 |
| disruptive | 327 | 920 | 478 | 1076 |
| missense | 152 | 691 | 396 | 866 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 91 | 526 | 229 | 392 |
| disruptive | 579 | 1879 | 762 | 1664 |
| missense | 279 | 1393 | 637 | 1083 |
PlasmoDB Total SNPs: 774
Non-coding: 81 | Synonymous: 400 | Nonsynonymous: 290 | Stop Codon: 3
Protein Length: 5757 | Molecular Weight (kDa): 682.455
UniProt ID(s): Q8ILC9
PDB ID(s): None
Isoelectric Point: 8.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001965 | Zinc finger, PHD-type |
| PFam | PF13771 | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34403450 | A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion andvirulence in the malaria parasite Plasmodium falciparum. | Miao J, Wang C, ..., Cui L | 10.1371/journal.ppat.1009351 |