Genome location: Pf3D7_14_v3:1,341,334..1,342,539(+)
Genome classification: Core
Product Description: signal peptidase complex subunit SPC1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 3.4.21.89 (Signal peptidase I)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030176 | integral component of endoplasmic reticulum membrane |
| Component | GO:0005787 | signal peptidase complex |
| Process | GO:0045047 | protein targeting to ER |
| Process | GO:0006465 | signal peptide processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.11 | 0.92 |
| Schizont | expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.04 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1433600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.972 | MFS: -2.271 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILC7
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.21.89 | Signal peptidase I | NEMSDSEDTAMG132cholateantipainL685,458rifampicinBAL0019193arylomycinlactacystindeoxycholate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103297
Most Similar Human Ortholog: A0A5F9YFS9
TM-align score: 0.68 | RMSD: 2.36
Seq Identity: 0.32 | Length: 85 / 101
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000114902 | signal peptidase complex subunit 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 0 | 8 |
| disruptive | 1 | 2 | 9 | 12 |
| missense | 1 | 2 | 9 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 9 | 2 | 9 |
| disruptive | 1 | 14 | 14 | 31 |
| missense | 1 | 14 | 12 | 16 |
PlasmoDB Total SNPs: 40
Non-coding: 39 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 101 | Molecular Weight (kDa): 11.573
UniProt ID(s): Q8ILC7
PDB ID(s): None
Isoelectric Point: 9.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009542 | Signal peptidase complex subunit Spc1/SPCS1 |
| InterPro | IPR037713 | Signal peptidase complex subunit Spc1 |
| PFam | PF06645 | Signal peptidase complex subunit Spc1/SPCS1 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30127496 | Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmicreticulum translocation interactome for export to the erythrocyte. | Marapana DS, Dagley LF, ..., Cowman AF | 10.1038/s41564-018-0219-2 |
| 36413467 | Absence of Wee1 alters global transcriptional response to oxidative stress inSchizosaccharomyces pombe | Datta S, Ghosal A, Dutta S, Sundaram G | 10.1093/femsle/fnac110 |
| 31477575 | Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway infission yeast | Morigasaki S, Chin LC, ..., Shiozaki K | 10.1242/jcs.236133 |
| 32554481 | Communication between Cyclin-dependent kinase Cdc2 and the Wis1-Spc1 MAPK pathwaydetermines mitotic timing in Schizosaccharomyces pombe | Ghosal A, Sarkar P, Sundaram G | 10.1242/bio.053322 |
| 35770329 | Transcription factor Atf1-dependent degradation of the mitotic cyclin Cdc13 isregulated by multiple factors in Schizosaccharomyces pombe | Basu S, Ghosh P, ..., Sundaram G | 10.1002/1873-3468.14439 |