Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Process | GO:0009657 | plastid organization |
Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.10 | 0.95 |
Trophozoite | expressed | 0.73 | 0.61 |
Schizont | expressed | 0.66 | 0.66 |
Gametocyte | possibly expressed | 0.85 | 0.58 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1433800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.099 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILC5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 38 | 124 | 71 | 165 |
disruptive | 130 | 374 | 185 | 470 |
missense | 87 | 293 | 158 | 375 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 58 | 252 | 111 | 198 |
disruptive | 230 | 709 | 347 | 649 |
missense | 130 | 552 | 273 | 469 |
PlasmoDB Total SNPs: 497
Non-coding: 101 | Synonymous: 174 | Nonsynonymous: 222 | Stop Codon: 0
Protein Length: 2688 | Molecular Weight (kDa): 326.012
UniProt ID(s): Q8ILC5
PDB ID(s): None
Isoelectric Point: 9.37
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
30726238 | A mutagenesis screen for essential plastid biogenesis genes in human malariaparasites. | Tang Y, Meister TR, ..., Yeh E | 10.1371/journal.pbio.3000136 |
33370279 | Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoroninmutants in Plasmodium falciparum. | Sharma AI, Shin SH, ..., Wirth DF | 10.1371/journal.pgen.1009266 |