About Gene List

PF3D7_1433800

Genome location: Pf3D7_14_v3:1,350,120..1,359,111(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Process GO:0009657 plastid organization
Process GO:0009410 response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite expressed 0.73 0.61
Schizont expressed 0.66 0.66
Gametocyte possibly expressed 0.85 0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1433800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.099 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILC5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532425

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 38 124 71 165
disruptive 130 374 185 470
missense 87 293 158 375

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 58 252 111 198
disruptive 230 709 347 649
missense 130 552 273 469

PlasmoDB Total SNPs: 497

Non-coding: 101 | Synonymous: 174 | Nonsynonymous: 222 | Stop Codon: 0

Protein Information

Protein Length: 2688 | Molecular Weight (kDa): 326.012

UniProt ID(s): Q8ILC5

PDB ID(s): None

Isoelectric Point: 9.37

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30726238 A mutagenesis screen for essential plastid biogenesis genes in human malariaparasites. Tang Y, Meister TR, ..., Yeh E 10.1371/journal.pbio.3000136
33370279 Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoroninmutants in Plasmodium falciparum. Sharma AI, Shin SH, ..., Wirth DF 10.1371/journal.pgen.1009266