Genome location: Pf3D7_14_v3:1,364,611..1,366,364(-)
Genome classification: Core
Product Description: CCR4-associated factor 16, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030014 | CCR4-NOT complex |
| Component | GO:0016020 | membrane |
| Function | GO:0042626 | ATPase-coupled transmembrane transporter activity |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.19 | 0.91 |
| Trophozoite | expressed | 0.40 | 0.77 |
| Schizont | possibly expressed | 0.04 | 0.98 |
| Gametocyte | not expressed | 0.09 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1434000
Resistome Missense Mutations: H189Q
Resistome Compounds with Missense Mutations: MMV007224
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -3.1 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1010800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1010800)
Modification: Disrupted | RMgm-2763
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILC3
"Best" AlphaFill ligand hit: TTP (thymidine-5'-triphosphate, Local RMSD=0.24) with 5TF8 (Global RMSD=4.00)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 14 | 12 | 18 |
| disruptive | 5 | 22 | 19 | 33 |
| missense | 5 | 22 | 19 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 32 | 16 | 14 |
| disruptive | 8 | 53 | 24 | 58 |
| missense | 8 | 46 | 22 | 52 |
PlasmoDB Total SNPs: 136
Non-coding: 130 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 257 | Molecular Weight (kDa): 30.199
UniProt ID(s): Q8ILC3
PDB ID(s): None
Isoelectric Point: 6.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003439 | ABC transporter-like |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00005 | ABC transporter-like |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29326268 | Mapping the malaria parasite druggable genome by using in vitro evolution andchemogenomics. | Cowell AN, Istvan ES, ..., Winzeler EA | 10.1126/science.aan4472 |
| 20626860 | Global expression studies in baker's yeast reveal target genes for theimprovement of industrially-relevant traits: the cases of CAF16 and ORC2 | Perez-Torrado R, Panadero J, ..., Randez-Gil F | 10.1186/1475-2859-9-56 |