Genome location: Pf3D7_14_v3:1,368,249..1,371,883(-)
Genome classification: Core
Product Description: calmodulin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005509 | calcium ion binding |
| Function | GO:0048306 | calcium-dependent protein binding |
| Function | GO:0030234 | enzyme regulator activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0055074 | calcium ion homeostasis |
| Process | GO:0019722 | calcium-mediated signaling |
| Process | GO:0044409 | entry into host |
| Process | GO:0000226 | microtubule cytoskeleton organization |
| Process | GO:0006508 | proteolysis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.16 | 0.92 |
| Trophozoite | expressed | 0.67 | 0.63 |
| Schizont | expressed | 0.77 | 0.57 |
| Gametocyte | expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1434200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.133 | MFS: -3.037 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: P62203
"Best" AlphaFill ligand hit: TAM (tris(hydroxyethyl)aminomethane, Local RMSD=0.15) with 2YGG (Global RMSD=3.06)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P27482 | Calmodulin-like protein 3 | HOGENOM, OrthoDB, OrthoMCL BLAST | CHEMBL5183837CHEMBL5189056CHEMBL5202730cid_441401 | |
| P62157 | Calmodulin | Bos taurus | HOGENOM, OMA, OrthoDB, OrthoMCL BLAST | PrenylamineCHEMBL41631med.21724, Compound 15MLS000069570... |
| P0DP23 | Calmodulin-1 | OMA, OrthoDB, OrthoMCL BLAST | TrifluperazineUS11542290, Compound A-7US11542290, Compound MT-002US11542290, Compound MT-003... |
Ortholog Group (OrthoMCL): OG6_100851
Most Similar Human Ortholog: P0DP24
TM-align score: 0.96 | RMSD: 0.91
Seq Identity: 0.89 | Length: 149 / 149
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143933 | calmodulin 2 |
| ENSG00000160014 | calmodulin 3 |
| ENSG00000198668 | calmodulin 1 |
Protein Length: 149 | Molecular Weight (kDa): 16.931
UniProt ID(s): A0A144A1Y0, P24044, P62203
PDB ID(s): None
Isoelectric Point: 3.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002048 | EF-hand domain |
| InterPro | IPR011992 | EF-hand domain pair |
| InterPro | IPR018247 | EF-Hand 1, calcium-binding site |
| InterPro | IPR039030 | Calmodulin |
| PFam | PF13499 | EF-hand domain |
| Superfamily | SSF47473 | EF-hand domain pair |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 138
Non-coding: 136 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18165240 | Role of Ca2+/calmodulin-PfPKB signaling pathway in erythrocyte invasion byPlasmodium falciparum. | Vaid A, Thomas DC, Sharma P | 10.1074/jbc.M708465200 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 29913151 | Plasmodium falciparum histidine triad protein and calmodulin modulates calciumhomeostasis and intracellular proteolysis. | Gomes Smaul MM, Budu A, ..., Gazarini ML | 10.1016/j.bbrc.2018.06.067 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |