About Gene List

PF3D7_1434400

Genome location: Pf3D7_14_v3:1,375,352..1,377,636(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite possibly expressed 0.06 0.96
Schizont expressed 1.48 0.43
Gametocyte expressed 0.35 0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1434400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.488 | MFS: -2.586 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1010400)

  • Relative Growth Rate: 0.05 ± 0.13
  • Confidence: 5.48

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILC0

"Best" AlphaFill ligand hit: BU2 (1,3-butanediol, Local RMSD=1.48) with 2RFM (Global RMSD=16.66)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_140578

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 14 10 14
disruptive 1 24 11 23
missense 0 21 11 18

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 29 12 17
disruptive 14 55 36 78
missense 9 38 22 62

PlasmoDB Total SNPs: 171

Non-coding: 157 | Synonymous: 6 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 285 | Molecular Weight (kDa): 33.719

UniProt ID(s): Q8ILC0

PDB ID(s): None

Isoelectric Point: 7.32

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30053874 Immunological characterization of Plasmodium vivax Pv32, a novel predictedGPI-anchored merozoite surface protein. Cheng Y, Wang B, ..., Han ET 10.1186/s12936-018-2401-7
34956931 Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening ofPlasmodium falciparum. Hou N, Li S, ..., Chen Q https://pubmed.ncbi.nlm.nih.gov/34956931/