Product Description: dynein-related AAA-type ATPase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 9
EC Numbers: 3.6.4.2 (Transferred entry: 5.6.1.2)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016020 | membrane |
| Component | GO:0030687 | preribosome, large subunit precursor |
| Process | GO:0006364 | rRNA processing |
| Process | GO:0000027 | ribosomal large subunit assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 2.21 | 0.22 |
| Trophozoite | possibly expressed | 2.13 | 0.18 |
| Schizont | possibly expressed | 0.73 | 0.65 |
| Gametocyte | not expressed | 2.04 | 0.20 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1434500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3.037 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1345800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.4.2 | dynein ATPase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100908
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 8105
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112159 | midasin AAA ATPase 1 |
| ENSG00000288121 | midasin AAA ATPase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 86 | 401 | 216 | 518 |
| disruptive | 419 | 1328 | 726 | 1650 |
| missense | 264 | 1035 | 619 | 1364 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 152 | 749 | 326 | 563 |
| disruptive | 769 | 2610 | 1135 | 2232 |
| missense | 460 | 1994 | 902 | 1597 |
PlasmoDB Total SNPs: 1167
Non-coding: 99 | Synonymous: 548 | Nonsynonymous: 520 | Stop Codon: 0
Protein Length: 8105 | Molecular Weight (kDa): 971.013
UniProt ID(s): Q8ILB9
PDB ID(s): None
Isoelectric Point: 7.94
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR011704 | ATPase, dynein-related, AAA domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036465 | von Willebrand factor A-like domain superfamily |
| InterPro | IPR040848 | Midasin, AAA lid domain 7 |
| InterPro | IPR041190 | Midasin AAA lid domain 5 |
| PFam | PF07728 | ATPase, dynein-related, AAA domain |
| PFam | PF17865 | Midasin AAA lid domain 5 |
| PFam | PF17867 | Midasin, AAA lid domain 7 |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF53300 | von Willebrand factor A-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |