Genome location: Pf3D7_14_v3:1,406,574..1,408,705(-)
Genome classification: Core
Product Description: mitochondrial import inner membrane translocase subunit TIM17, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005744 | TIM23 mitochondrial import inner membrane translocase complex |
| Component | GO:0031305 | integral component of mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0030150 | protein import into mitochondrial matrix |
| Process | GO:0006626 | protein targeting to mitochondrion |
| Process | GO:0015031 | protein transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.09 | 0.94 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.09 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1434700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1010100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1010100)
Modification: Disrupted | RMgm-2758
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILB7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101935
Most Similar Human Ortholog: Q99595
TM-align score: 0.83 | RMSD: 1.84
Seq Identity: 0.52 | Length: 143 / 162
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126768 | translocase of inner mitochondrial membrane 17B |
| ENSG00000134375 | translocase of inner mitochondrial membrane 17A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 118
Non-coding: 111 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 162 | Molecular Weight (kDa): 17.909
UniProt ID(s): Q8ILB7
PDB ID(s): None
Isoelectric Point: 9.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | PF02466 | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 27991487 | The non-canonical mitochondrial inner membrane presequence translocase oftrypanosomatids contains two essential rhomboid-like proteins | Harsman A, Oeljeklaus S, ..., Schneider A | 10.1038/ncomms13707 |
| 38193679 | Distinct structural motifs are necessary for targeting and import of Tim17 inTrypanosoma brucei mitochondrion | Darden C, Donkor JE, ..., Chaudhuri M | 10.1128/msphere.00558-23 |
| 28965880 | The divergent N-terminal domain of Tim17 is critical for its assembly in the TIMcomplex in Trypanosoma brucei | Weems E, Singha UK, Smith JT, Chaudhuri M | 10.1016/j.molbiopara.2017.09.003 |
| 32339625 | Role of the translocase of the mitochondrial inner membrane in the import oftRNAs into mitochondria in Trypanosoma brucei | Barozai MYK, Chaudhuri M | 10.1016/j.gene.2020.144705 |
| 37461662 | Distinct structural motifs are necessary for targeting and import of Tim17 inTrypanosoma brucei mitochondrion | Darden C, Donkor J, ..., Chaudhuri M | 10.1101/2023.07.07.548172 |