Product Description: mitochondrial acidic protein MAM33, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0097177 | mitochondrial ribosome binding |
| Function | GO:0008494 | translation activator activity |
| Process | GO:0070131 | positive regulation of mitochondrial translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.17 | 0.92 |
| Trophozoite | expressed | 0.90 | 0.54 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | possibly expressed | 0.39 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1434800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.509 | MFS: -2.449 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILB6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 17 | 6 | 8 |
| disruptive | 0 | 5 | 4 | 12 |
| missense | 0 | 5 | 4 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 21 | 5 | 12 |
| disruptive | 1 | 16 | 15 | 40 |
| missense | 1 | 13 | 9 | 31 |
PlasmoDB Total SNPs: 96
Non-coding: 95 | Synonymous: 0 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 252 | Molecular Weight (kDa): 28.872
UniProt ID(s): Q8ILB6
PDB ID(s): None
Isoelectric Point: 4.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003428 | Mitochondrial glycoprotein |
| InterPro | IPR036561 | Mitochondrial glycoprotein superfamily |
| PFam | PF02330 | Mitochondrial glycoprotein |
| Superfamily | SSF54529 | Mitochondrial glycoprotein superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 31339607 | Identification of the Toxoplasma gondii mitochondrial ribosome, andcharacterisation of a protein essential for mitochondrial translation. | Lacombe A, Maclean AE, ..., Sheiner L | 10.1111/mmi.14357 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |