PF3D7_1434900

Genome location: Pf3D7_14_v3:1,411,737..1,413,096(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	possibly expressed	0.03	0.98
Gametocyte	expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1434900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.04 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1009900)

Relative Growth Rate: 0.97 ± 0.15
Confidence: 5.13

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1009900)

Modification: Disrupted | RMgm-2757

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILB5

"Best" AlphaFill ligand hit: ETM (2-(trimethylammonium)ethyl thiol, Local RMSD=0.94) with 1QWZ (Global RMSD=19.61)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532756

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	13	12	18
disruptive	7	46	24	65
missense	7	43	23	61

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	29	11	26
disruptive	16	93	46	82
missense	14	85	44	64

PlasmoDB Total SNPs: 43

Non-coding: 20 | Synonymous: 12 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 327 | Molecular Weight (kDa): 38.411

UniProt ID(s): Q8ILB5

PDB ID(s): None

Isoelectric Point: 8.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A