Genome location: Pf3D7_14_v3:1,413,760..1,415,729(+)
Genome classification: Core
Product Description: cytochrome c oxidase assembly protein COX15, putative
SignalP Peptide: N/A
# Transmembrane Domains: 8
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0016653 | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor |
| Process | GO:0006784 | heme A biosynthetic process |
| Process | GO:0008535 | respiratory chain complex IV assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.17 | 0.89 |
| Schizont | expressed | 0.08 | 0.94 |
| Gametocyte | expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1435000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.159 | MFS: -3.169 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1009800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILB4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102761
Most Similar Human Ortholog: Q7KZN9
TM-align score: 0.79 | RMSD: 2.37
Seq Identity: 0.35 | Length: 349 / 430
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000014919 | cytochrome c oxidase assembly homolog COX15 |
| ENSG00000285932 | novel transcript |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 7 | 25 |
| disruptive | 7 | 40 | 31 | 69 |
| missense | 7 | 38 | 30 | 60 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 39 | 11 | 26 |
| disruptive | 17 | 99 | 51 | 100 |
| missense | 16 | 87 | 47 | 81 |
PlasmoDB Total SNPs: 94
Non-coding: 79 | Synonymous: 9 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 430 | Molecular Weight (kDa): 50.425
UniProt ID(s): Q8ILB4
PDB ID(s): None
Isoelectric Point: 10.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003780 | COX15/CtaA family |
| InterPro | IPR023754 | Heme A synthase, type 2 |
| PFam | PF02628 | COX15/CtaA family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |