PF3D7_1435200

Genome location: Pf3D7_14_v3:1,418,686..1,421,491(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.03	0.99
Trophozoite	expressed	0.10	0.94
Schizont	expressed	0.67	0.63
Gametocyte	expressed	1.29	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1435200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.975 | MFS: -2.739 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1009600)

Modification: Disrupted | RMgm-2754

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILB2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533408

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	20	7	30
disruptive	7	47	24	70
missense	7	46	22	65

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	35	27	28
disruptive	16	109	45	100
missense	12	94	42	67

PlasmoDB Total SNPs: 175

Non-coding: 155 | Synonymous: 13 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 359 | Molecular Weight (kDa): 42.108

UniProt ID(s): Q8ILB2

PDB ID(s): None

Isoelectric Point: 9.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A