Genome location: Pf3D7_14_v3:1,433,279..1,434,985(-)
Genome classification: Core
Product Description: ER membrane protein complex subunit 4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0072546 | EMC complex |
| Process | GO:0034975 | protein folding in endoplasmic reticulum |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.23 | 0.88 |
| Trophozoite | expressed | 0.41 | 0.75 |
| Schizont | expressed | 0.13 | 0.91 |
| Gametocyte | expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1435400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.202 | MFS: -3.298 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1009400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILB0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102320
Most Similar Human Ortholog: Q5J8M3
TM-align score: 0.59 | RMSD: 3.57
Seq Identity: 0.24 | Length: 137 / 190
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000128463 | ER membrane protein complex subunit 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 87
Non-coding: 71 | Synonymous: 13 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 190 | Molecular Weight (kDa): 21.835
UniProt ID(s): Q8ILB0
PDB ID(s): None
Isoelectric Point: 10.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009445 | TMEM85/ER membrane protein complex subunit 4 |
| PFam | PF06417 | TMEM85/ER membrane protein complex subunit 4 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 28677085 | Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in eukaryoticinitiation factor 2B (eIF2B)-mediated translation control and stress response | Sharma S, Sourirajan A, Dev K | 10.1007/s13205-017-0857-8 |
| 32476094 | Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays acrucial role in eIF2B-mediated translation regulation and survival under stressconditions | Sharma S, Sourirajan A, Baumler DJ, Dev K | 10.1186/s43141-020-00029-7 |
| 18586032 | Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibithydrogen peroxide mediated cell death in yeast | Ring G, Khoury CM, ..., Greenwood MT | 10.1016/j.febslet.2008.06.042 |