Genome location: Pf3D7_14_v3:1,435,333..1,437,346(+)
Genome classification: Core
Product Description: clathrin light chain, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.27 | 0.87 |
| Trophozoite | expressed | 0.49 | 0.71 |
| Schizont | possibly expressed | 0.27 | 0.82 |
| Gametocyte | expressed | 0.42 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1435500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.305 | MFS: -2.753 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILA9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 14 | 9 | 16 |
| disruptive | 4 | 25 | 20 | 40 |
| missense | 2 | 21 | 20 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 29 | 11 | 14 |
| disruptive | 10 | 74 | 35 | 81 |
| missense | 5 | 56 | 23 | 52 |
PlasmoDB Total SNPs: 113
Non-coding: 94 | Synonymous: 15 | Nonsynonymous: 3 | Stop Codon: 1
Protein Length: 254 | Molecular Weight (kDa): 30.48
UniProt ID(s): Q8ILA9
PDB ID(s): None
Isoelectric Point: 4.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000996 | Clathrin light chain |
| PFam | PF01086 | Clathrin light chain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 38374962 | Comparative dose effectiveness of intravenous and intrathecal AAV9.CB7.hIDS,RGX-121, in mucopolysaccharidosis type II mice | Smith MC, Belur LR, ..., McIvor RS | 10.1016/j.omtm.2024.101201 |