Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.95 |
| Trophozoite | not expressed | 0.18 | 0.90 |
| Schizont | expressed | 1.77 | 0.39 |
| Gametocyte | expressed | 1.32 | 0.39 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1435600
Resistome Missense Mutations: N1589S
Resistome Compounds with Missense Mutations: GNF-Pf-5611
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -2.908 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILA8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_115766
Most Similar Human Ortholog: O76013
TM-align score: 0.38 | RMSD: 5.97
Seq Identity: 0.08 | Length: 261 / 1788
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126337 | keratin 36 |
| ENSG00000197079 | keratin 35 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 88 | 36 | 146 |
| disruptive | 60 | 279 | 132 | 373 |
| missense | 36 | 204 | 107 | 297 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 36 | 168 | 86 | 135 |
| disruptive | 144 | 562 | 268 | 494 |
| missense | 73 | 421 | 205 | 341 |
PlasmoDB Total SNPs: 249
Non-coding: 67 | Synonymous: 113 | Nonsynonymous: 69 | Stop Codon: 0
Protein Length: 1788 | Molecular Weight (kDa): 210.712
UniProt ID(s): Q8ILA8
PDB ID(s): None
Isoelectric Point: 8.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |