Product Description: ataxin-2 like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0010494 | cytoplasmic stress granule |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003723 | RNA binding |
| Process | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly |
| Process | GO:0034063 | stress granule assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1435700.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.521 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILA7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 46 | 18 | 63 |
| disruptive | 10 | 70 | 50 | 134 |
| missense | 8 | 65 | 47 | 115 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 82 | 48 | 69 |
| disruptive | 23 | 187 | 130 | 255 |
| missense | 17 | 157 | 108 | 187 |
PlasmoDB Total SNPs: 331
Non-coding: 292 | Synonymous: 23 | Nonsynonymous: 16 | Stop Codon: 0
Protein Length: 908 | Molecular Weight (kDa): 105.193
UniProt ID(s): Q8ILA7
PDB ID(s): None
Isoelectric Point: 9.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009604 | LsmAD domain |
| InterPro | IPR025852 | Ataxin 2, SM domain |
| PFam | PF06741 | LsmAD domain |
| PFam | PF14438 | Ataxin 2, SM domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |