About Gene List

PF3D7_1435700

Genome location: Pf3D7_14_v3:1,444,537..1,450,925(-)

Genome classification: Core

Function and Localization

Product Description: ataxin-2 like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0010494 cytoplasmic stress granule
Component GO:0005739 mitochondrion
Function GO:0003723 RNA binding
Process GO:0010603 regulation of cytoplasmic mRNA processing body assembly
Process GO:0034063 stress granule assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed nd nd
Trophozoite expressed nd nd
Schizont expressed nd nd
Gametocyte expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1435700.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.521 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILA7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_117869

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 46 18 63
disruptive 10 70 50 134
missense 8 65 47 115

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 82 48 69
disruptive 23 187 130 255
missense 17 157 108 187

PlasmoDB Total SNPs: 331

Non-coding: 292 | Synonymous: 23 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 908 | Molecular Weight (kDa): 105.193

UniProt ID(s): Q8ILA7

PDB ID(s): None

Isoelectric Point: 9.3

Protein Domain Annotations:

Source Family ID Description
InterPro IPR009604 LsmAD domain
InterPro IPR025852 Ataxin 2, SM domain
PFam PF06741 LsmAD domain
PFam PF14438 Ataxin 2, SM domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104