PF3D7_1435900

Genome location: Pf3D7_14_v3:1,454,227..1,455,651(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	expressed	0.07	0.95
Schizont	possibly expressed	0.01	0.99
Gametocyte	expressed	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1435900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.179 | MFS: -3.263 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1008900)

Relative Growth Rate: 0.13 ± 0.04
Confidence: 7.66

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILA5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156378

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	16	8	21
disruptive	6	23	11	40
missense	6	23	11	38

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	25	15	21
disruptive	9	57	19	78
missense	9	51	18	54

PlasmoDB Total SNPs: 109

Non-coding: 80 | Synonymous: 11 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 313 | Molecular Weight (kDa): 38.13

UniProt ID(s): Q8ILA5

PDB ID(s): None

Isoelectric Point: 8.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR021150	Ubiquinol-cytochrome c chaperone/UPF0174
PFam	PF03981	Ubiquinol-cytochrome c chaperone/UPF0174
Superfamily	N/A	N/A