PF3D7_1436100

Genome location: Pf3D7_14_v3:1,460,988..1,468,298(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.49	0.77
Trophozoite	expressed	0.87	0.54
Schizont	expressed	0.38	0.78
Gametocyte	possibly expressed	0.95	0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1436100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.99 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1008700)

Relative Growth Rate: 0.89 ± 0.14
Confidence: 5.37

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_1008700)

Modification: Disrupted | RMgm-4326

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILA3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532855

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	83	50	104
disruptive	72	195	140	337
missense	49	166	114	280

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	169	70	126
disruptive	161	469	246	500
missense	82	368	177	367

PlasmoDB Total SNPs: 332

Non-coding: 108 | Synonymous: 143 | Nonsynonymous: 81 | Stop Codon: 0

Protein Information

Protein Length: 1949 | Molecular Weight (kDa): 235.196

UniProt ID(s): Q8ILA3

PDB ID(s): None

Isoelectric Point: 9.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF69349	N/A
Superfamily	SSF81324

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895