Genome location: Pf3D7_14_v3:1,467,461..1,474,935(-)
Genome classification: Core
Product Description: basal complex protein BCP1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045178 | basal part of cell |
| Component | GO:0070258 | inner membrane pellicle complex |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.26 | 0.87 |
| Trophozoite | not expressed | 0.27 | 0.85 |
| Schizont | expressed | 2.05 | 0.35 |
| Gametocyte | possibly expressed | 0.62 | 0.68 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1436200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.197 | MFS: -2.717 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILA2
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.88) with 6JWQ (Global RMSD=32.82)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 96 | 60 | 128 |
| disruptive | 94 | 382 | 217 | 451 |
| missense | 61 | 322 | 187 | 384 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 33 | 192 | 91 | 159 |
| disruptive | 186 | 793 | 350 | 656 |
| missense | 115 | 646 | 291 | 474 |
PlasmoDB Total SNPs: 323
Non-coding: 38 | Synonymous: 166 | Nonsynonymous: 119 | Stop Codon: 0
Protein Length: 2269 | Molecular Weight (kDa): 270.478
UniProt ID(s): Q8ILA2
PDB ID(s): None
Isoelectric Point: 8.42
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 31097714 | An essential contractile ring protein controls cell division in Plasmodiumfalciparum. | Rudlaff RM, Kraemer S, Streva VA, Dvorin JD | 10.1038/s41467-019-10214-z |
| 32805410 | The crystal structure of protein-transporting chaperone BCP1 from Saccharomycescerevisiae | Lin MH, Kuo PC, ..., Hsu CH | 10.1016/j.jsb.2020.107605 |
| 36746591 | Structure and potential anti-fatigue mechanism of polysaccharides from Bupleurumchinense DC | Jiang P, Ji X, ..., Jiao L | 10.1016/j.carbpol.2023.120608 |