PF3D7_1436400

Genome location: Pf3D7_14_v3:1,483,903..1,488,496(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.18	0.91
Trophozoite	expressed	0.25	0.85
Schizont	expressed	0.05	0.97
Gametocyte	expressed	0.40	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1436400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.926 | MFS: -2.64 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1008400)

Relative Growth Rate: 0.06 ± 0.05
Confidence: 7.58

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3I5

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.14) with 6CTA (Global RMSD=14.45)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532313

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	58	29	61
disruptive	36	165	103	224
missense	23	148	93	203

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	100	47	67
disruptive	64	359	138	280
missense	40	296	126	213

PlasmoDB Total SNPs: 143

Non-coding: 56 | Synonymous: 54 | Nonsynonymous: 33 | Stop Codon: 0

Protein Information

Protein Length: 1264 | Molecular Weight (kDa): 153.329

UniProt ID(s): C6S3I5

PDB ID(s): None

Isoelectric Point: 9.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A