Product Description: histidine triad protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.1.29 (Bis(5'-adenosyl)-triphosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0008270 | zinc ion binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.09 | 0.95 |
| Trophozoite | possibly expressed | 0.18 | 0.89 |
| Schizont | possibly expressed | 0.07 | 0.94 |
| Gametocyte | possibly expressed | 0.23 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1436900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.53 | MFS: -2.972 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0611900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0611900)
Modification: Disrupted | RMgm-2105
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL97
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.1.29 | bis(5'-adenosyl)-triphosphatase | ATPADPAMPEDTAsuraminsperminediethyl dicarbonateadenosine 5'-phosphosulfateP1,P3-bis(5'-adenosyl) triphosphateadenosine 5'-O-(gamma-fluorotriphosphate)adenosine 5'-O-(gamma-fluoromonophosphate)O,O'-bis[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl] O,O'-(2-hydroxypropane-1,3-diyl) bis[hydrogen (phosphorothioate)]... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P49789 | Bis(5'-adenosyl)-triphosphatase | Homo sapiens | HOGENOM, OMA, OrthoDB, OrthoMCL BLAST | AppppA analog, 1 (X=O)AppppA analog, 2 (X=S)AppppA analog, 5 (X=O)AppppA analog, 5 (X=S)... |
| P9WMK9 | AP-4-A phosphorylase | OrthoMCL | Synthesized Sulfanylacrylonitril Derivatives 2Synthesized Sulfanylacrylonitril Derivatives 5Synthesized Sulfanylacrylonitril Derivatives 9Synthesized Sulfanylacrylonitril Derivatives 10... |
Ortholog Group (OrthoMCL): OG6_101676
Most Similar Human Ortholog: E9PBZ0
TM-align score: 0.96 | RMSD: 0.68
Seq Identity: 0.28 | Length: 78 / 200
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000189283 | fragile histidine triad diadenosine triphosphatase |
Protein Length: 200 | Molecular Weight (kDa): 23.595
UniProt ID(s): Q8IL97
PDB ID(s): 5CS2
Isoelectric Point: 6.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001310 | Histidine triad (HIT) protein |
| InterPro | IPR019808 | Histidine triad, conserved site |
| InterPro | IPR036265 | HIT-like superfamily |
| InterPro | IPR039383 | FHIT family |
| PFam | PF01230 | Histidine triad (HIT) protein |
| Superfamily | SSF54197 | HIT-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 103
Non-coding: 96 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29913151 | Plasmodium falciparum histidine triad protein and calmodulin modulates calciumhomeostasis and intracellular proteolysis. | Gomes Smaul MM, Budu A, ..., Gazarini ML | 10.1016/j.bbrc.2018.06.067 |