Genome location: Pf3D7_14_v3:1,502,507..1,505,459(+)
Genome classification: Core
Product Description: N-acetyltransferase, GNAT family
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 2.3.1.- (Transferring groups other than amino-acyl groups.);2.3.1.1 (Amino-acid N-acetyltransferase);2.3.1.48 (Histone acetyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005634 | nucleus |
| Function | GO:0008080 | N-acetyltransferase activity |
| Process | GO:0020014 | schizogony |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.50 | 0.76 |
| Trophozoite | expressed | 0.68 | 0.62 |
| Schizont | expressed | 0.48 | 0.70 |
| Gametocyte | expressed | 0.54 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1437000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.046 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0611800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL96
"Best" AlphaFill ligand hit: ACO (acetyl coenzyme *a, Local RMSD=3.12) with 6AO7 (Global RMSD=14.12)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.- | Ex: [myelin-proteolipid] O-palmitoyltransferase | CoAKClArgATPADPEDTAMgCl2CaCl2MnCl2AgNO3CoCl2FeSO4... |
| 2.3.1.1 | amino-acid N-acetyltransferase | CoAKClArgEDTAMgCl2CaCl2MnCl2AgNO3CoCl2FeSO4FeCl3BaCl2... |
| 2.3.1.48 | histone acetyltransferase | CoADNARNABF1EDTAMB-3LTK14PU139A-485TTK21CPTH2CPTH6... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 42 | 18 | 39 |
| disruptive | 16 | 87 | 30 | 83 |
| missense | 12 | 59 | 19 | 60 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 70 | 25 | 33 |
| disruptive | 47 | 176 | 71 | 214 |
| missense | 30 | 110 | 55 | 128 |
PlasmoDB Total SNPs: 215
Non-coding: 150 | Synonymous: 44 | Nonsynonymous: 21 | Stop Codon: 0
Protein Length: 544 | Molecular Weight (kDa): 64.188
UniProt ID(s): Q8IL96
PDB ID(s): None
Isoelectric Point: 8.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000182 | GNAT domain |
| InterPro | IPR016181 | Acyl-CoA N-acyltransferase |
| PFam | PF00583 | GNAT domain |
| Superfamily | SSF55729 | Acyl-CoA N-acyltransferase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 35621049 | N-acetylation of secreted proteins in Apicomplexa is widespread and isindependent of the E R acetyl-Co A transporter A T1 | Nyonda MA, Boyer JB, ..., Giglione C | 10.1242/jcs.259811 |
| 36744402 | An essential endoplasmic reticulum-resident N-acetyltransferase ortholog in Plasmodium falciparum | Polino AJ, Hasan MM, ..., Goldberg DE | 10.1242/jcs.260551 |