About Gene List

PF3D7_1437100

Genome location: Pf3D7_14_v3:1,505,496..1,506,974(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 1.00
Trophozoite not expressed 0.07 0.95
Schizont possibly expressed 0.02 0.98
Gametocyte expressed 0.12 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1437100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.203 | MFS: -3.156 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL95

"Best" AlphaFill ligand hit: CLR (cholesterol, Local RMSD=0.16) with 4XNV (Global RMSD=9.18)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533041

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 6 2 8
disruptive 2 21 15 30
missense 2 21 14 26

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 13 6 8
disruptive 3 57 16 51
missense 3 51 13 31

PlasmoDB Total SNPs: 72

Non-coding: 65 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 158 | Molecular Weight (kDa): 18.454

UniProt ID(s): Q8IL95

PDB ID(s): None

Isoelectric Point: 10.18

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF57802 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895