Genome location: Pf3D7_14_v3:1,530,017..1,532,363(-)
Genome classification: Core
Product Description: trafficking protein particle complex subunit 5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030008 | TRAPP complex |
| Component | GO:1990070 | TRAPPI protein complex |
| Component | GO:1990071 | TRAPPII protein complex |
| Component | GO:1990072 | TRAPPIII protein complex |
| Component | GO:0020002 | host cell plasma membrane |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.09 | 0.93 |
| Schizont | possibly expressed | 0.02 | 0.98 |
| Gametocyte | not expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1437800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.926 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0611000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7KQM2
"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=8.27) with 4IV0 (Global RMSD=14.82)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102532
Most Similar Human Ortholog: Q8IUR0
TM-align score: 0.87 | RMSD: 1.92
Seq Identity: 0.36 | Length: 174 / 184
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000181029 | trafficking protein particle complex 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 108
Non-coding: 95 | Synonymous: 13 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 184 | Molecular Weight (kDa): 21.512
UniProt ID(s): A0A144A213, P15847, Q549B9, Q7KQM2
PDB ID(s): None
Isoelectric Point: 7.7
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007194 | Transport protein particle (TRAPP) component |
| InterPro | IPR016696 | TRAPP I complex, subunit 5 |
| InterPro | IPR024096 | NO signalling/Golgi transport ligand-binding domain superfamily |
| PFam | PF04051 | Transport protein particle (TRAPP) component |
| Superfamily | SSF111126 | NO signalling/Golgi transport ligand-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 2693962 | A new blood stage antigen of Plasmodium falciparum transported to the erythrocytesurface. | Knapp B, Hundt E, Kupper HA | 10.1016/0166-6851(89)90101-1 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |