Product Description: eukaryotic translation initiation factor eIF2A, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0043022 | ribosome binding |
| Function | GO:0000049 | tRNA binding |
| Function | GO:0003743 | translation initiation factor activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.84 | 0.61 |
| Trophozoite | expressed | 0.76 | 0.58 |
| Schizont | expressed | 0.32 | 0.79 |
| Gametocyte | expressed | 0.60 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1438000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.687 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL87
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101886
Most Similar Human Ortholog: C9IZE1
TM-align score: 0.80 | RMSD: 2.26
Seq Identity: 0.21 | Length: 211 / 661
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000144895 | eukaryotic translation initiation factor 2A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 42 | 25 | 43 |
| disruptive | 9 | 39 | 29 | 76 |
| missense | 7 | 39 | 28 | 68 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 74 | 38 | 45 |
| disruptive | 21 | 99 | 60 | 131 |
| missense | 15 | 81 | 50 | 103 |
PlasmoDB Total SNPs: 165
Non-coding: 119 | Synonymous: 32 | Nonsynonymous: 13 | Stop Codon: 1
Protein Length: 661 | Molecular Weight (kDa): 76.833
UniProt ID(s): Q8IL87
PDB ID(s): None
Isoelectric Point: 9.4
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011387 | Translation initiation factor 2A |
| InterPro | IPR013979 | Translation initiation factor, beta propellor-like domain |
| PFam | PF08662 | Translation initiation factor, beta propellor-like domain |
| Superfamily | SSF82171 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |