Genome location: Pf3D7_14_v3:1,540,920..1,543,553(-)
Genome classification: Core
Product Description: translocation protein SEC62, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005784 | Sec61 translocon complex |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Process | GO:0031204 | posttranslational protein targeting to membrane, translocation |
| Process | GO:0045047 | protein targeting to ER |
| Process | GO:0043952 | protein transport by the Sec complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.33 | 0.84 |
| Trophozoite | expressed | 0.62 | 0.64 |
| Schizont | expressed | 0.57 | 0.67 |
| Gametocyte | expressed | 0.30 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1438100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.169 | MFS: -2.953 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1302200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL86
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 21 | 18 | 31 |
| disruptive | 0 | 12 | 8 | 32 |
| missense | 0 | 12 | 8 | 29 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 44 | 16 | 21 |
| disruptive | 3 | 38 | 22 | 74 |
| missense | 2 | 32 | 18 | 50 |
PlasmoDB Total SNPs: 98
Non-coding: 87 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 377 | Molecular Weight (kDa): 43.937
UniProt ID(s): Q8IL86
PDB ID(s): None
Isoelectric Point: 7.65
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004728 | Translocation protein Sec62 |
| PFam | PF03839 | Translocation protein Sec62 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17919451 | Unraveling the components of protein translocation pathway in human malariaparasite Plasmodium falciparum. | Tuteja R | 10.1016/j.abb.2007.08.031 |
| 30127496 | Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmicreticulum translocation interactome for export to the erythrocyte. | Marapana DS, Dagley LF, ..., Cowman AF | 10.1038/s41564-018-0219-2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |