Genome location: Pf3D7_14_v3:1,561,526..1,563,812(+)
Genome classification: Core
Product Description: Golgi to ER traffic protein 4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071818 | BAT3 complex |
| Component | GO:0005829 | cytosol |
| Function | GO:0005515 | protein binding |
| Process | GO:0045048 | protein insertion into ER membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.14 | 0.93 |
| Trophozoite | expressed | 0.19 | 0.87 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1438600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -3.008 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL82
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103135
Most Similar Human Ortholog: Q7L5D6
TM-align score: 0.74 | RMSD: 3.78
Seq Identity: 0.17 | Length: 265 / 277
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000239857 | guided entry of tail-anchored proteins factor 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 19 | 5 | 21 |
| disruptive | 5 | 11 | 9 | 32 |
| missense | 5 | 11 | 9 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 36 | 8 | 18 |
| disruptive | 8 | 38 | 24 | 58 |
| missense | 6 | 31 | 19 | 38 |
PlasmoDB Total SNPs: 104
Non-coding: 89 | Synonymous: 9 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 277 | Molecular Weight (kDa): 33.15
UniProt ID(s): Q8IL82
PDB ID(s): None
Isoelectric Point: 7.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007317 | Golgi to ER traffic protein 4 |
| PFam | PF04190 | Golgi to ER traffic protein 4 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34780541 | A conserved guided entry of tail-anchored pathway is involved in the traffickingof a subset of membrane proteins in Plasmodium falciparum. | Kumar T, Maitra S, Rahman A, Bhattacharjee S | 10.1371/journal.ppat.1009595 |
| 33542241 | Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2in yeast | Zhang Y, De Laurentiis E, ..., Rospert S | 10.1038/s41467-021-20981-3 |
| 37882342 | Proteome-wide abundance profiling of yeast deletion strains for GET pathwaymembers using sample multiplexing | Gygi JS, Liu X, Levi BP, Paulo JA | 10.1002/pmic.202300303 |