Genome location: Pf3D7_14_v3:1,570,403..1,574,738(+)
Genome classification: Core
Product Description: male development protein MD1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0043021 | ribonucleoprotein complex binding |
| Process | GO:0007530 | sex determination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.04 | 0.98 |
| Trophozoite | possibly expressed | 0.03 | 0.99 |
| Schizont | possibly expressed | 0.16 | 0.90 |
| Gametocyte | expressed | 1.86 | 0.33 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1438800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.999 | MFS: -2.432 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1302700)
Modification: Disrupted | RMgm-5076
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A3K9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 38 | 27 | 61 |
| disruptive | 6 | 35 | 22 | 67 |
| missense | 6 | 34 | 22 | 66 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 82 | 40 | 61 |
| disruptive | 17 | 102 | 46 | 126 |
| missense | 15 | 91 | 41 | 96 |
PlasmoDB Total SNPs: 204
Non-coding: 171 | Synonymous: 26 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 699 | Molecular Weight (kDa): 83.953
UniProt ID(s): A0A144A3K9
PDB ID(s): None
Isoelectric Point: 6.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR025605 | OST-HTH/LOTUS domain |
| InterPro | IPR025677 | OST-HTH associated domain |
| PFam | PF12872 | OST-HTH/LOTUS domain |
| PFam | PF14418 | OST-HTH associated domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 38148574 | The Plasmodium falciparum CCCH zinc finger protein MD3 regulates malegametocytogenesis through its interaction with RNA-binding proteins | Farrukh A, Musabyimana JP, ..., Ngwa CJ | 10.1111/mmi.15215 |