Genome location: Pf3D7_14_v3:1,577,456..1,579,573(+)
Genome classification: Core
Product Description: copper transporter
SignalP Peptide: MCKNIYFYIILILKLFIVLA
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020002 | host cell plasma membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0005375 | copper ion transmembrane transporter activity |
| Process | GO:0006878 | cellular copper ion homeostasis |
| Process | GO:0006825 | copper ion transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.08 | 0.94 |
| Schizont | expressed | 0.11 | 0.92 |
| Gametocyte | expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1439000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -2.749 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1302900)
Modification: Disrupted | RMgm-1379
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL79
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 12 | 2 | 13 |
| disruptive | 3 | 19 | 11 | 38 |
| missense | 3 | 19 | 11 | 36 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 13 | 14 |
| disruptive | 9 | 52 | 29 | 76 |
| missense | 7 | 47 | 27 | 46 |
PlasmoDB Total SNPs: 75
Non-coding: 61 | Synonymous: 5 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 235 | Molecular Weight (kDa): 27.151
UniProt ID(s): Q8IL79
PDB ID(s): None
Isoelectric Point: 7.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007274 | Ctr copper transporter |
| PFam | PF04145 | Ctr copper transporter |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23190769 | A Plasmodium falciparum copper-binding membrane protein with copper transportmotifs. | Choveaux DL, Przyborski JM, Goldring JP | 10.1186/1475-2875-11-397 |