PF3D7_1439200

Genome location: Pf3D7_14_v3:1,588,952..1,593,131(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.20	0.90
Trophozoite	not expressed	0.40	0.76
Schizont	not expressed	0.12	0.92
Gametocyte	not expressed	0.82	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1439200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.218 | #Insertions: 10

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1303100)

Relative Growth Rate: 1.08 ± 0.14
Confidence: 5.39

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1303100)

Modification: Disrupted | RMgm-3413

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL77

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=2.95) with 6JWY (Global RMSD=21.44)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215380

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	57	35	76
disruptive	24	147	98	252
missense	24	146	95	233

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	112	49	94
disruptive	57	362	152	365
missense	40	320	133	278

PlasmoDB Total SNPs: 161

Non-coding: 96 | Synonymous: 32 | Nonsynonymous: 33 | Stop Codon: 0

Protein Information

Protein Length: 1226 | Molecular Weight (kDa): 148.167

UniProt ID(s): Q8IL77

PDB ID(s): None

Isoelectric Point: 9.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A