Product Description: Sad1/UNC domain-containing protein, putative
SignalP Peptide: MIWWFLISVNFLFFLIKS
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0044228 | host cell surface |
| Component | GO:0016020 | membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.84 | 0.61 |
| Trophozoite | possibly expressed | 1.12 | 0.45 |
| Schizont | expressed | 1.07 | 0.45 |
| Gametocyte | not expressed | 1.05 | 0.47 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1439300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.15 | MFS: -2.883 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL76
"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=3.16) with 4KFT (Global RMSD=16.20)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103990
Most Similar Human Ortholog: B4DYM4
TM-align score: 0.26 | RMSD: 5.92
Seq Identity: 0.17 | Length: 287 / 1803
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000094975 | SUN domain containing ossification factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 89 | 52 | 119 |
| disruptive | 51 | 249 | 140 | 361 |
| missense | 40 | 229 | 135 | 324 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 26 | 181 | 85 | 124 |
| disruptive | 118 | 556 | 247 | 510 |
| missense | 78 | 482 | 220 | 379 |
PlasmoDB Total SNPs: 243
Non-coding: 100 | Synonymous: 83 | Nonsynonymous: 58 | Stop Codon: 2
Protein Length: 1803 | Molecular Weight (kDa): 220.747
UniProt ID(s): Q8IL76
PDB ID(s): None
Isoelectric Point: 9.66
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR012919 | SUN domain |
| PFam | PF07738 | SUN domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 29162636 | Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum SurfaceAntigens and Possible Vaccine Candidates. | Nilsson Bark SK, Ahmad R, ..., Marti M | 10.1074/mcp.RA117.000076 |