Product Description: cytochrome b-c1 complex subunit Rieske, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.10.2.2 (Transferred entry: 7.1.1.8);7.1.1.8 (Quinol--cytochrome-c reductase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005750 | mitochondrial respiratory chain complex III |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0016491 | oxidoreductase activity |
| Function | GO:0008121 | ubiquinol-cytochrome-c reductase activity |
| Process | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c |
| Process | GO:0055114 | oxidation-reduction process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.14 | 0.90 |
| Schizont | expressed | 0.20 | 0.85 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1439400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.876 | MFS: -2.584 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL75
"Best" AlphaFill ligand hit: PEE (dope, Local RMSD=0.12) with 4U3F (Global RMSD=6.66)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101749
Most Similar Human Ortholog: P47985
TM-align score: 0.57 | RMSD: 3.10
Seq Identity: 0.39 | Length: 178 / 355
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000169021 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 21 | 7 | 15 |
| disruptive | 5 | 8 | 4 | 30 |
| missense | 5 | 8 | 4 | 29 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 33 | 9 | 24 |
| disruptive | 7 | 35 | 33 | 85 |
| missense | 6 | 29 | 27 | 65 |
PlasmoDB Total SNPs: 58
Non-coding: 48 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 355 | Molecular Weight (kDa): 40.981
UniProt ID(s): Q8IL75
PDB ID(s): None
Isoelectric Point: 7.54
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005805 | Rieske iron-sulphur protein, C-terminal |
| InterPro | IPR006317 | Ubiquinol-cytochrome c reductase, iron-sulphur subunit |
| InterPro | IPR014349 | Rieske iron-sulphur protein |
| InterPro | IPR017941 | Rieske [2Fe-2S] iron-sulphur domain |
| InterPro | IPR036922 | Rieske [2Fe-2S] iron-sulphur domain superfamily |
| PFam | PF00355 | Rieske [2Fe-2S] iron-sulphur domain |
| Superfamily | SSF50022 | Rieske [2Fe-2S] iron-sulphur domain superfamily |
| Superfamily | SSF81502 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |