Genome location: Pf3D7_14_v3:1,606,643..1,611,876(+)
Genome classification: Core
Product Description: oocyst rupture protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071944 | cell periphery |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.78 | 0.66 |
| Trophozoite | possibly expressed | 0.18 | 0.89 |
| Schizont | expressed | 1.04 | 0.46 |
| Gametocyte | not expressed | 0.29 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1439500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.492 | #Insertions: 9
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1303400)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1303400)
Modification: Mutated | RMgm-4560
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL74
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101766
Most Similar Human Ortholog: Q5T6K7
TM-align score: 0.77 | RMSD: 2.60
Seq Identity: 0.46 | Length: 116 / 1074
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000066136 | nuclear transcription factor Y subunit gamma |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 53 | 32 | 63 |
| disruptive | 74 | 192 | 90 | 202 |
| missense | 37 | 144 | 65 | 147 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 115 | 52 | 60 |
| disruptive | 123 | 399 | 171 | 397 |
| missense | 66 | 296 | 116 | 181 |
PlasmoDB Total SNPs: 381
Non-coding: 153 | Synonymous: 116 | Nonsynonymous: 112 | Stop Codon: 0
Protein Length: 1074 | Molecular Weight (kDa): 123.019
UniProt ID(s): Q8IL74
PDB ID(s): None
Isoelectric Point: 8.17
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007125 | Histone H2A/H2B/H3 |
| InterPro | IPR009072 | Histone-fold |
| PFam | PF00125 | Histone H2A/H2B/H3 |
| Superfamily | SSF47113 | Histone-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 27982038 | Release of Plasmodium sporozoites requires proteins with histone-folddimerization domains. | Curra C, Gessmann R, ..., Siden-Kiamos I | 10.1038/ncomms13846 |
| 30287363 | Extraction, preliminary characterization and in vitro antioxidant activity ofpolysaccharides from Oudemansiella radicata mushroom | Wang Y, Jia J, ..., Zhang Q | 10.1016/j.ijbiomac.2018.09.209 |
| 30391497 | Identification of Plasmodium berghei Oocyst Rupture Protein 2 (ORP2) domainsinvolved in sporozoite egress from the oocyst | Siden-Kiamos I, Pace T, ..., Curra C | 10.1016/j.ijpara.2018.09.004 |