Genome location: Pf3D7_14_v3:1,612,049..1,613,376(-)
Genome classification: Core
Product Description: cytochrome c oxidase subunit NDUFA4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.32 | 0.80 |
| Schizont | expressed | 0.49 | 0.68 |
| Gametocyte | expressed | 0.81 | 0.56 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1439600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -2.71 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL73
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 8 | 3 | 13 |
| disruptive | 0 | 6 | 6 | 15 |
| missense | 0 | 6 | 6 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 21 | 5 | 10 |
| disruptive | 1 | 38 | 25 | 42 |
| missense | 0 | 25 | 16 | 36 |
PlasmoDB Total SNPs: 44
Non-coding: 40 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 180 | Molecular Weight (kDa): 22.559
UniProt ID(s): Q8IL73
PDB ID(s): None
Isoelectric Point: 9.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23049965 | Subcompartmentalisation of proteins in the rhoptries correlates with orderedevents of erythrocyte invasion by the blood stage malaria parasite. | Zuccala ES, Gout AM, ..., Baum J | 10.1371/journal.pone.0046160 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |