Product Description: vesicle-associated membrane protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0005886 | plasma membrane |
| Process | GO:0090158 | endoplasmic reticulum membrane organization |
| Process | GO:0061817 | endoplasmic reticulum-plasma membrane tethering |
| Process | GO:0061025 | membrane fusion |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.15 | 0.93 |
| Trophozoite | expressed | 0.55 | 0.68 |
| Schizont | expressed | 0.37 | 0.76 |
| Gametocyte | expressed | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1439800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.134 | MFS: -3.157 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1303700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL71
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101143
Most Similar Human Ortholog: E5RK64
TM-align score: 0.88 | RMSD: 1.06
Seq Identity: 0.36 | Length: 67 / 241
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101558 | VAMP associated protein A |
| ENSG00000124164 | VAMP associated protein B and C |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 11 | 15 | 13 |
| disruptive | 1 | 4 | 6 | 23 |
| missense | 1 | 4 | 6 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 38 | 14 | 12 |
| disruptive | 2 | 29 | 29 | 68 |
| missense | 2 | 20 | 24 | 46 |
PlasmoDB Total SNPs: 94
Non-coding: 89 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 241 | Molecular Weight (kDa): 27.687
UniProt ID(s): Q8IL71
PDB ID(s): None
Isoelectric Point: 7.9
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000535 | Major sperm protein (MSP) domain |
| InterPro | IPR008962 | PapD-like superfamily |
| InterPro | IPR016763 | Vesicle-associated membrane-protein-associated protein |
| PFam | PF00635 | Major sperm protein (MSP) domain |
| Superfamily | SSF49354 | PapD-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |