About Gene List

PF3D7_1440000

Genome location: Pf3D7_14_v3:1,624,013..1,631,734(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite expressed 0.81 0.58
Schizont expressed 0.82 0.58
Gametocyte possibly expressed 0.88 0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1440000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.494 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL70

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.36) with 2BVL (Global RMSD=24.42)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533003

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 18 129 74 155
disruptive 86 354 229 483
missense 57 310 209 434

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 35 253 102 158
disruptive 168 713 333 663
missense 115 607 288 522

PlasmoDB Total SNPs: 335

Non-coding: 119 | Synonymous: 106 | Nonsynonymous: 110 | Stop Codon: 0

Protein Information

Protein Length: 2204 | Molecular Weight (kDa): 259.001

UniProt ID(s): Q8IL70

PDB ID(s): None

Isoelectric Point: 7.46

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108