Genome location: Pf3D7_14_v3:1,632,713..1,636,867(-)
Genome classification: Core
Product Description: cohesin complex subunit RAD21
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0008278 | cohesin complex |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.66 | 0.63 |
| Schizont | expressed | 1.06 | 0.49 |
| Gametocyte | not expressed | 0.44 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1440100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.341 | MFS: -2.607 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1304000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL69
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 51 | 28 | 73 |
| disruptive | 31 | 132 | 84 | 184 |
| missense | 19 | 123 | 79 | 173 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 99 | 52 | 88 |
| disruptive | 60 | 279 | 144 | 305 |
| missense | 41 | 247 | 128 | 248 |
PlasmoDB Total SNPs: 144
Non-coding: 51 | Synonymous: 52 | Nonsynonymous: 41 | Stop Codon: 0
Protein Length: 1014 | Molecular Weight (kDa): 118.503
UniProt ID(s): Q8IL69
PDB ID(s): None
Isoelectric Point: 4.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006910 | Rad21/Rec8-like protein, N-terminal |
| PFam | PF04825 | Rad21/Rec8-like protein, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31390575 | Landscape of the Plasmodium Interactome Reveals Both Conserved andSpecies-Specific Functionality. | Hillier C, Pardo M, ..., Choudhary JS | 10.1016/j.celrep.2019.07.019 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |